ALDINGA Beach, Port Noarlunga and Reynella are among the southern suburbs tipped to be the best sellers in 2014.
Real estate agents say the region will experience a property boom off the back of the completion of the Southern Expressway duplication and opening of the Seaford Rail Line extension.
Ray White Aberfoyle Park principal Scott Ellis said his prediction for the top performing suburbs were at the "lower end of the market".
"Suburbs like Hackham, Christie Downs, Reynella and Aberfoyle Park will be 2014's best performing suburbs," Mr Ellis told the Southern Times Messenger.
"With the two large infrastructure projects, being the Seaford Rail extension and the Southern Expressway duplication, nearing completion there will no longer be any speculation as to the potential positive effects.
"It will be a vast improvement for local residents so therefore a great opportunity for buyers to get in early before these effects are realised.
"First National Real Estate Willunga director Nick van Vliet predicted McLaren Vale, McLaren Flat and Willunga would be the best performers in 2014."These suburbs are appealing because they offer a family friendly, country living lifestyle with large land sizes," Mr van Vliet said.
"Aldinga Beach looks set to be a great performer too because it offers brilliant coastal living."
Mr van Vliet expected the Southern Expressway duplication to entice "city slickers" to the south.
"The south is a popular choice with new buyers, as they see it as a family friendly area, offering real value for money combined with a wonderful lifestyle," he said.
"The expressway going two ways, at last, may entice those people to consider moving to the southern vales more seriously."
Timms Real Estate Christies Beach director Valerie Timms said Port Noarlunga, Seaford and Woodcroft would also be attractive to buyers this year.
She said the lifestyle was what made the south so popular with buyers.
"Where else can you purchase new builds with access to good schools, shops and still be minutes from wineries, world class beaches and eateries along with an easy commute to the city?" Mrs Timms said.
"Those who traditionally sought homes and accommodation closer to the city will find the more affordable price tag on rentals and homes to buy, simply too good to ignore.
"We anticipate a strong resurgence in the southern real estate market and a positive recovery in the market in 2014."
Onkaparinga Council figures show there were 533 houses approved by its Development Assessment Panel from July to December 2013, compared to 479 in the same period in 2012.
The council received 2275 development applications, totalling more than $201 million, between July 1 and December 30 last year.
This is on track to top the 2012/13 financial year's 3730 development applications totalling more than $317 million.
Onkaparinga Mayor Lorraine Rosenberg agreed the completion of the rail extension and the expressway would lead to a property boom.
"The council is certainly ready to handle the expected growth and we look forward to having a booming south," Ms Rosenberg said.